Restoring Aging Genes in Rats
Overexpression of a protein that regulates calcium homeostasis in hippocampal neurons can safely and effectively reverse and prevent age-related memory impairments in rats while restoring altered gene expression, finds .
Philip Landfield, John Gant, Eric Blalock and colleagues found that long-term and short-term treatment of aging rats that induces overexpression of FK506-Binding Protein 12.6/1b (FKBP1b) restored the expression of more than 800 genes affected by aging to levels comparable to those of young untreated rats, in addition to improving performance on a water maze task. The restored genes represent a new genomic network that regulates the integrity of neuronal structure in the hippocampus and is targeted by aging. These results suggest that addressing FKBP1b deficiency may represent a new avenue for countering age-related memory loss.
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Corresponding author: Philip Landfield (University of Kentucky, Lexington, KY, USA), pwland@uky.edu
