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Overcoming the High Multiplexing Barrier: 3D Spatial Omics in One Go, Powered by Leica Microsystems

We will elaborate on experimental design and considerations to perform high multiplexing imaging experiments beyond 10 fluorophores on a single sample. We will discuss appropriate fluorophore panels, sample preparation details and tools required for imaging, and show how imaging high multiplexing targets on a single sample can be exploited for 3D spatial omics analysis. Aivia, Leica's cutting-edge image analysis software, enables robust and efficient analysis of multiplexing imaging data.

Leica Microsystems    
Booth #:  965
 

Connect, Scale, Explore! Your New Inscopix Miniscope Ecosystem

Join us into the realm of integrated neuroscience. In the ever-evolving field, one must position themselves for success with new skills, technologies, and ideas. We present the latest multi-modal miniscope technologies, designed to enhance productivity and provide a unified environment to accelerate you to publication. Whether you're a scientist, a lab group, or in biotech, choose and scale the right solution for your research, saving valuable time and effort and transform your discoveries!

Bruker Corporation    
Booth #:  424

Neural Cell Paint Nite: Unveiling the Complexity of Brain Tissue With Cell Painting and Spatial Biology

Brain tissue is a complex system. Learning multiparameter techniques helps you understand proteins, cell function, and/or cellular phenotypes present in an experiment. Join us for a 20 min presentation on how to stain neural cells or brain tissue samples with Cell Painting assays and Spatial Biology reagents.

Thermo Fisher Scientific
Booth #: 610

CorePlate™: Revolutionizing Organoid Analysis

The showcase will highlight advantages of our CorePlate™ microchip, using thousands of electrodes on ultrathin microneedles to access inner layers of structured tissue. It allows non-destructive, label-free, real-time, and parallel recording of neurons, providing a detailed description of the functional activity in iPSC-derived brain organoids. CorePlate™ enhances data quality and reduces variability, advancing the study of neurodegenerative diseases and drug discovery.

3Brain AG
Booth #:  478

Imaging the Dynamics of the Nervous System

Two-photon microscopy in neuroscience has unraveled many mysteries of perception, computation, and connectivity. Ca2+ imaging has illuminated brain function with resolution and precision at the scale of small networks, single cells, dendrites, and individual spines. Join us to learn how the Bruker Ultima 2Pplus and Investigator workstations combine holographic optogenetic activation, GRIN lenses, and the NeuraLeap rapid-focusing module to advance new frontiers in neural circuit interrogation.

Bruker Corporation 
Booth #:  424
 

Experimental Refinement in ºÚÁÏÉç Research: A Cornerstone for Holistic Investigation and Increased Translation

A holistic and interdisciplinary research approach is vital to neuroscience investigation. Integrating refined methodologies provides converging evidence from in vitro and in vivo experiments that translate to complex neurological adaptations in humans. Harvard Biosciences (HB) is a world-leading technological innovator supporting neuroscience investigation. HB focuses on refining and integrating experimental platforms to facilitate mechanistic findings and increase research translation.

Harvard Bioscience
Booth #:  925

Unlocking Super-Resolution in ºÚÁÏÉç Across Scales With the New ZEISS Lattice SIM Family

Today’s research problems require a balance of sample size, imaging speed, and super-resolution capabilities. Discover how the new ZEISS Lattice SIM Family acquires entire brain sections at blistering speeds with SIM Apotome mode, captures dynamic events of subcellular structures with Lattice SIM, and resolves the molecular details of neurons with effortless super resolution across scales. Join us to see how ZEISS Lattice SIM Family can transform your neuroscience research.

ZEISS Microscopy
Booth #: 653

Unlocking the Full Potential of Multi-Well High-Density Microelectrode Arrays (HD-MEAs)

This session showcases MaxTwo, a cutting-edge electrophysiology platform with densely packed microelectrodes in a multi-well format, capturing electrogenic cell signals with unprecedented resolution. It enhances experiments by combining the highest electrode density with a fast, automatic data analysis pipeline, delivering high-content, high-quality data. Also, MaxTwo can be integrated with the first dedicated perfusion system for multi-well HD-MEAs, setting a new standard in the market.

MaxWell Biosystems    
Booth #:  365

Supporting Collective Momentum in ALS Drug Discovery

Significant advances in genetics, pathology, biomarkers and endpoints within ALS drug discovery have driven the recent approval of several disease modifying therapies for this progressive and irreversible neurodegenerative disease. This session will outline how cellular and animal models can replicate disease pathology, and can be interrogated with translational readouts to support clinical success for small molecules, ASOs, and gene therapies.

Charles River
Booth #:  417

The Single Cell Era, Scaled. Achieve Maximum Throughput at Minimal Cost With Scale Biosciences

Scale Biosciences is pushing the boundaries of what is possible in single-cell omics.  In this presentation, we will familiarize the audience with our expanding portfolio of library preparation solutions, which cover multiple cellular analytes and up to millions of cells in a single experimental output using highly parallelized analyte barcoding techniques.

Scale Biosciences    
Booth #:  1414
 

Rigorous and Reproducible Western Blots: A How-To Guide for Protein Quantification

In this seminar, we will give you the tips and tools for Western blot success! We will review the Western blotting workflow, from electrophoresis to immunodetection, and discuss how to troubleshoot issues at each step. Additionally, we will introduce innovations designed by MilliporeSigma to streamline Western blotting workflows including the new mPAGE® Lux Gel Casting System.

MilliporeSigma
Booth #:  1015

Unlock the Potential of Your Precious Samples with the Singulator Platform

Case studies showcasing successful applications of the Singulator Platform in neuroscience research will be shared, illustrating how this tool is unlocking new possibilities for understanding the complexities of the brain. Attendees will gain insights into how the Singulator Platform can enhance their research workflows, ultimately accelerating discoveries in neuroscience.

S2 Genomics
Booth#:  1515  

Building a Functional Atlas of Macaque Brain Using Stereo-seq

Understanding the spatial organization of cell types in the brain is crucial for unraveling its complex functional and anatomical architecture. I will present a spatial transcriptomic atlas of a macaque hemisphere using the Stereo-seq platform combined with structural and functional magnetic resonance imaging (MRI) and histological staining. Together, these data offer insight into the spatial distribution of diverse cell types and their relationship to anatomical and functional boundaries.

STOmics Americas
Booth #1539

Microscoop: A Subcellular Pickable Microscope for Proteomic Discovery

Do you know most of the 80(?) protein species at primary cilia distal tips or 100(?) protein species at the lipid-mitochondria interfaces? Syncell's Microscoop™ enables precise isolation and identification of proteins at the organelle level, using automated microscopy-guided photo-biotinylation and AI image analysis. With mass spectrometry, it identifies proteins in cellular structures like cilia and synapses, enhancing subcellular proteomics with high resolution and specificity.

Syncell, Inc.    
Booth #:  606

Simple Western Capillary Immunoassays: A Game Changer in Elucidating Intracellular Signaling in Alzheimer’s Disease

Simple Western™ is a well-established capillary immunoassay technology that bridges the gap between ELISA and Western blot, combining protein size characterization and analytical grade quantification without matrix effects, from just 3 µL of sample. Learn how we used Simple Western to study TREM2 signaling in a model for Alzheimer’s disease.

Bio-Techne    
Booth #:  1165

Tackling the Reproducibility Crisis: The Need for Standardised Human Cell Models for ºÚÁÏÉç Research, Drug Discovery, and Therapies

The lack of standardised reagents hinders reliable experimental comparisons, impeding research, drug development and translational efforts.
For human cell models, such as primary cells, cell lines and patient-derived iPSC-derived cells, biological variability and lack of reproducibility also remain a challenge.
This expert panel will explore how standardising human iPSC-derived cells can bring consistency, reproducibility and regulatory compliance, enhancing research outcomes.

bit.bio 
Booth #:  1545

Highest Plex Spatial Multiomics as a Discovery Tool for Cellular Aging and Pathogenesis in Alzheimer's Disease

Alzheimer’s tau forms neurofibrillary tangles (NFT), correlated with neuron loss, cognitive decline, & cellular senescence. Exploring senescence transition, cell interactions, & tissue-wide effects requires high-resolution spatial solutions. CosMx SMI reveals spatially correlated gene modules & cell niches. High-plex multiomics, (GeoMx DSP), gives insight into NFT-associated senescence & neurotoxicity. A phospho-tau signature (CellScape) demonstrates rapid scale up model for disease evaluation.

Bruker Corporation
Booth # 424

Luxendo Light-Sheet and Acquifer Automated Microscopy: Smart 3D Imaging From High-Resolution to High-Throughput

Experience 3D life across scales with Luxendo SPIMs for long-term imaging of living samples and the Acquifer IM for automated screening microscopy. Discover smart adaptive light-sheet fluorescence microscopy for long-term 3D imaging of both live, and large cleared biological samples. The Acquifer IM offers automated phenotypic screening with an intuitive imaging interface and the Acquifer HIVE is the complete solution for secure storage and processing of all imaging, sequencing, and omics data.

Bruker Corporation
Booth #:  424    

Iconeus One: Pioneering Real-time Whole-Brain Imaging with Functional Ultrasound

Boost your research with functional ultrasound (fUS) imaging – an innovative technique delivering unparalleled resolution and sensitivity. Delve into functional connectivity mapping, real-time brain activity monitoring, and super-resolution vascular imaging. Elevate your understanding of neural dynamics and vascular responses with Iconeus One, transforming the landscape of preclinical research.

Iconeus   
Booth #: 1465

Using Human Stem Cell-Derived Neural Organoids for Modeling Disease

In this talk, we will introduce the various types of neural organoids offered by STEMCELL Technologies. We will review how to generate cerebral, midbrain, and spinal cord organoids, demonstrating which cell types you can expect from each. Finally, we will show how each type of organoid can be used to model different diseases such as microcephaly, epilepsy, Parkinson's disease and amyotrophic lateral sclerosis, highlighting the use of BrainPhys™ when measuring organoid activity in vitro.

STEMCELL Technologies Inc.
Booth #:   866

Spatial and single cell multiome sequencing of human brain tissue

Join us to learn how Chromium Single Cell, Visium Spatial, and Xenium In Situ platforms from 10x Genomics can help you push the boundaries of your research. Uncover molecular insights, dissect cell-type differences, detect novel subtypes and biomarkers, decipher spatial gene expression patterns, and more. Enabling deeper insight into cancer, immunology, neuroscience, and developmental biology, 10x Genomics gives researchers the ability to see biology in new ways.

10x Genomics
Booth #1417

Exploring 5mC and 5hmC Methylation Modifications in the Parkinson’s Disease Brain

Using Biomodal’s duet multiomics solution evoC, we examined 5mC and 5hmC methylation marks in postmortem brain tissue from individuals with Parkinson’s disease and controls. Our study reveals disease-specific alterations in methylation patterns, observed at both the genome-wide and gene-specific levels. We also analysed the methylation signatures of genes known to be associated with Parkinson’s disease. This work offers comprehensive insights into the epigenetic mechanisms underlying Parkinson’s disease.

biomodal    
Booth#:  1279